OmpF, as one of the best-studied bacterial porins on structural and functional characteristics (70–74), has been reported to be a protective antigen against some bacterial infections (40, 74–77) and been predicted to be a conserved porin located on the surface of Yersinia (42), which suggests it is possible to use as an immunogen candidate providing immunoprotection against Yersinia infection. Here, VDAC1 is linked to bacterial infectious disease.