On the other hand, genes downregulated in VH11 CLL were involved in quite diverse pathways, including interleukin-, epidermal growth factor receptor (EGFR)-, vascular endothelial growth factor (VEGF)-mediated signaling, metabolic processes, hypoxia and the UV radiation-induced stress response (Figure 5B, Supplementary Table 3A). Here, VEGFA is linked to B-cell chronic lymphocytic leukemia.