To identify the gene signature underlying the clustering of αIgM-stimulated B cells and VH11 CLL, as well as α-CD40/IL-4-stimulated B cells and non-VH11 CLL, we performed hierarchical clustering analyses to separate the 148 genes into 4 clusters (Figure 6B, Supplementary Table 3B). The gene discussed is IL4; the disease is B-cell chronic lymphocytic leukemia.