This latter group of T cell-dependent unmutated CLL displayed an expression signature, as defined by 13 genes including the CCDC88A-CLIP3-ZCCHC18-CHD3-ITM2A module, that is not only different from TI unmutated CLL, but also from mutated CLL in the IgH.TEμ mouse model. Here, ITM2A is linked to B-cell chronic lymphocytic leukemia.