Some of these genes have already been shown to play a role in hematologic malignancies, including CLL (Pim-2, Met, Rgs16, Ccdc88a, Zcchc18, Clip3) (38–42), diffuse large B cell lymphoma, follicular lymphoma (Vav3) (43), acute lymphoblastic leukemia (ALL) (Itm2a, Chst1) (44, 45) or acute myeloid leukemia (AML) (Chd3) (46). This evidence concerns the gene VAV3 and acute lymphoblastic leukemia.