CD40LG and B-cell chronic lymphocytic leukemia: Taken together, these findings indicate that VH11/Vκ14-expressing CLL arise independently of T cell help or GC formation, whereas non-VH11 CLL is T cell-dependent and reduced in the absence of functional GCs in IgH.TEμ.Cd40l−/−and IgH.TEμ.Aicda−/− mice.