These include the regulator of G-protein signaling 16, Rgs16, which is upregulated in autoimmune B cells of BXD2 mice and enhances GC formation by the canonical NF-κB pathway, signifying the post-GC origin of non-VH11 CLL (52, 53). The gene discussed is NFKB1; the disease is B-cell chronic lymphocytic leukemia.