Most tissues and cell types produce IFN-1 when exposed to appropriate pathogen or danger-associated molecular patterns (Rauch et al., 2013).IFN-α1 gene transfer in in vivo models of breast cancer induced neovascularization and tumor growth. Gene therapy with IFN-α1 might be useful for treatment of breast cancer (Indraccolo et al., 2002). This evidence concerns the gene IFNA1 and breast carcinoma.