Elevated levels of PLAUR found in aggressive breast cancer. Anti-uPAR antibodies were effective at reducing breast tumor burden in vivo (LeBeau et al., 2013).Central mediator of growth factor-induced endothelial cell migration and angiogenesis in breast cancer (Poettler et al., 2012). The plasminogen activation system has a key role in the regulation of all the phases of the inflammation process (Del Rosso et al., 2008).Induced in udder tissue of heifers inoculated with Streptococcus uberis (de Greeff et al., 2013). The gene discussed is PLAUR; the disease is breast cancer.