Anti-tumor drugs have been protected through various methods for targeting certain specific cellular receptors such as EGFR or CD95, various drugs compositions or methods for drug production, formulation, or administration, various systems of drug transports through the BBB, inhibitors of protein kinase, antitumor vaccine comprising dendritic cells activated against the tumor, various immunogenic compositions containing for example heat chock proteins. This evidence concerns the gene EGFR and neoplasm.