Glioblastoma cell line xenografts, such as the commercially available GBM immortalized cell lines U87, U251, T98G, and A172, are usually relatively easy to grow, but these cell lines are reported to be quite different from a GBM of a human patient, being circumscribed, having different genotype (Huszthy et al., 2012), MHC and integrin expression (Huszthy et al., 2012), as well as lacking certain GBM features such as single-cell invasion, tumor necrosis, or microvascular proliferation (Mahesparan et al., 2003). This evidence concerns the gene HLA-C and glioblastoma.