Invariant Natural killer T (iNKT) cells recognize KRN7000 which is up-regulated in many cancers. NKT cells directly lyse the CD1d expressing tumor cells by using perforins. The infusion of iNKT cells and PD-1+CD8+T cells may reduce the tumor burden and improve survival (Wolf et al., 2018). The gene discussed is PRF1; the disease is neoplasm.