TNFRSF18 and neoplasm: INCAGN01876: An anti-human glucocorticoid-induced tumor necrosis factor receptor (TNF 18; GITR; CD357) agonistic humanized monoclonal antibody, with immune checkpoint modulating activity. Anti-GITR antibody INCAGN01876 binds to and activates GITRs present on T-cells activating tumor-antigen-specific T-effector cells (T effs), and suppressing the function of activated T-regulatory cells (Tregs). (Knee et al., 2016) Epacadostat: An inhibitor of IDO-3, which is an immunosuppressive enzyme that acts as an immune checkpoint.(Jochems et al., 2016)