INCAGN01949 is a humanized IgG1 agonistic monoclonal antibody which acts on a T cell co-stimulatory receptor, OX40 (CD134, TNFRSF4). This potentiates signaling by T cell receptor (TCR) during priming of CD4+ and CD8+ T cells and memory T cell recall responses. Besides, it also co-engages Fcγ receptors expressed by tumor-associated T effs which facilitates the selective depletion of intratumoral Tregs (Gonzalez et al., 2016). The gene discussed is CD8A; the disease is neoplasm.