In light of the functional nature of these readouts that cannot be captured by post-mortem assays and the fact that T2-weighted MRI sensitivity parallels histopathology (i.e., cresyl-violet) in detecting stroke volume in the focal cortical ET-1 model (Biernaskie et al., 2001), we used quantitative MRI of cerebral blood flow and intracerebral multielectrode electrophysiological recordings to compare stroke size and neurovascular state in the peri- and contra-lesional cortex 3 weeks following stroke induction. This evidence concerns the gene EDN1 and Stroke.