Zhao et al. (2017) evaluated the anti-epileptic effect of anti-HMGB1 mAb on human brain slices from clinical drug-resistant epilepsy patients (Table 3) where anti-HMGB1 mAb binds to HMGB1 and demonstrate long-lasting anti-epileptic properties, which is consistent with the previously estimated long half-time elimination in the brain (Zhang et al., 2011). This evidence concerns the gene HMGB1 and epilepsy.