HMGB1 acts as a pathogenic inflammatory response to mediate ranges of conditions such as epilepsy (Maroso et al., 2010), septic shock (Wang et al., 1999), ischemia (Kim et al., 2006; Wang et al., 2015), TBI (Okuma et al., 2012), PD (Sasaki et al., 2016), AD (Fujita et al., 2016), and MS (Andersson et al., 2008). Here, HMGB1 is linked to myeloid sarcoma.