For instance, lncRNA HOTTIP is up‐regulated in glioma cells treated by hypoxia, and knockdown of HIF‐1α and HOTTIP blocked hypoxia‐induced EMT, and suppressed invasion and migration of glioma cells by regulating the miR‐101/ZEB1 axis.23 HOXA11‐AS is significantly up‐regulated in glioma tissues and cell lines and its knockdown inhibits glioma cell proliferation, migration and invasion in vitro, and tumour growth in vivo, thereby via ceRNA for miR‐214‐3p and its direct target EZH2.24 This evidence concerns the gene HIF1A and central nervous system cancer.