Indeed, it has been shown that ciliopathy-associated proteins form different modules that cross talk and interact together.8, 40 Through the identification of ARL3 variants as a cause of JBTS, we show that ARL3 provides a hub within the network of ciliopathy-associated genes, whereby perturbation of ARL3 results in the mislocalization of multiple ciliary proteins, including INPP5E and NPHP3. Here, INPP5E is linked to Joubert syndrome.