However, in this case, being a tumor suppressor in the Hippo pathway, it is the high affinity of the Sav-RASSF-Hippo (SARAH) heterodimer of NORE1A and mammalian sterile 20-like kinase 1/2 (MST1/2) that shifts the equilibrium toward an active NORE1A species. Here, RASSF5 is linked to neoplasm.