TNFAIP3 and autoimmune disease: For example, GWAS and fine-mapping revealed several autoimmune disease risk variants in the chromosome 6q23 locus, including a tandem pair of systemic lupus erythematosus (SLE)-associated polymorphisms, rs148314165 (−T) and rs200820567 (T > A) (referred to as the TT > A variants), located in an ENCODE-identified putative enhancer region located ~ 42 kb downstream of the tumor necrosis factor alpha-induced protein 3 (TNFAIP3) gene promoter [55, 56].