CRP and Increased total leukocyte count: Time-graphs at the top of the page show the evolution of selected clinical (e.g. fever) and laboratory (e.g. leukocytosis, C-reactive protein (CRP)) variables and indicators of severity-of-illness (e.g. the arterial oxygen tension (PaO2)/fractional inspired oxygen (FiO2) ratio, sequential organ failure assessment score (SOFA)).