These results further supported the hypothesis that the sepsis-associated A risk allele of the rs153109 functional SNP enhanced promoter activity and gene transcription of IL-27, thereby directly or indirectly promoting sepsis-induced inflammatory responses, which ultimately resulted in the development of sepsis from sepsis subtype to severe sepsis/septic shock and poor prognosis, with potentially important therapeutic implications. This evidence concerns the gene IL27 and Sepsis.