IL27 and Sepsis: The sepsis-associated rs153109 (− 964 A > G) SNP within the promoter region of IL-27 was capable of increasing the transcription of the IL-27 gene by regulating its promoter activities, upregulating both transcription and translation of IL-27 and then enhancing the secretion of pro-inflammatory cytokines, which were closely associated with the severity of sepsis and poor outcome.