As shown in Table 4, the frequencies of the AA genotypes and A allele at the IL-27 SNP rs153109 A > G were significantly greater in the severe sepsis subgroup (P = 0.002 for genotype and allele) and septic shock subgroup (P = 0.0002 for genotype and P = 0.0003 for allele) compared to the sepsis subtype subgroup, which indicated a significant role of A allele in promoting the progression of sepsis from sepsis subtype to severe sepsis/septic shock. This evidence concerns the gene IL27 and Sepsis.