PF4 and ovarian carcinoma: Previous studies suggest that the expression of CXCL1, CXCL2, and CXCL4 is regulated by IKKβ in ovarian cancer cells.17 After incubation with inhibitors against IKKβ or p65 for 6 hours, the mRNA expression levels of CXCL1, CXCL2, and CXCL4 in HCT116 and HT29 cells were significantly reduced (Figure 4D).