In addition to acting as pro‐angiogenic factors, chemokines could also act as autocrine growth factors to affect the proliferation of tumor cells.25 The present study revealed that the suppression of CXCL1, CXCL2, or CXCL4 in CRC cells by GNA13 overexpression significantly inhibited clonogenic growth and cell proliferation. Here, GNA13 is linked to colorectal carcinoma.