Transfection of shCXCL1/2 and shCXCL4 into HCT116 and HT29 cells successfully suppressed CXCL1, CXCL2, and CXCL4 expression and resulted in suppressed clonogenic growth and cell proliferation (Figure 4A‐C), suggesting that these three chemokines could promote survival and proliferation in an autocrine manner in CRC cells that overexpress GNA13. This evidence concerns the gene GNA13 and colorectal carcinoma.