Epithelial‐mesenchymal transition is regarded as a critical step in tumor metastasis and invasion.23 It is known that CRC with EMT characteristics shows more vascular invasion and metastases and has a poorer prognosis.24 In our study, we revealed that GNA13 expression regulates EMT in CRC cells, suggesting that GNA13 drives tumor proliferation. This evidence concerns the gene GNA13 and neoplasm.