In summary, our study reveals that GNA13 overexpression upregulates the expression of CXCL1, CXCL2, and CXCL4, which are chemokines involved in the IKKβ/NF‐κB pathway, and these effects are crucial for the angiogenesis and progression of CRC. This evidence concerns the gene CXCL1 and colorectal carcinoma.