LGALS3 and cancer: It has been shown in several types of cancer that in response to chemotherapeutic agents (such as cisplatin, etoposide, Tumour Necrosis Factor-α (TNF-α), and nitric oxide), galectin-3 is transported from the nucleus to the cytoplasm, where it stimulates the phosphorylation of Bcl-2 associated death (Bad) protein and the reduction of Bad expression.