HSPA5 and retinal ischemia: To test whether GRP78 gene delivery was neuroprotective under other injury conditions in addition to TON, we examined RGC loss in a mouse model of retinal ischemia-reperfusion induced by transient elevation of IOP.16 Similarly, we found that AAV2-GRP78 significantly prevented RGC loss after ischemic injury (Supplementary Fig. S8).