PERK is known to activate GSK3β, which is one of the key kinases for tau phosphorylation, activate caspases that cleave tau, and directly phosphorylate tau on residues.47 These features have positioned PERK activation as an inducer for tauopathy and neurodegeneration, as tau phosphorylation and cleavage favor tau aggregation. This evidence concerns the gene MAPT and tauopathy.