To further investigate whether AAV2-mediated GRP78 overexpression is neuroprotective in retinal diseases, we used an ONC mouse model that has been widely used to study mechanisms and strategies for neuroprotection in TON.17 In this model, optic nerve injury is induced by a transient crush that triggers a degenerative response spreading retrogradely to RGC soma. The gene discussed is HSPA5; the disease is Abnormal retinal morphology.