Although the pathological aggregation of tau and its subsequent deposition in NFTs are defining histopathological features of Alzheimer's disease and many other neurodegenerative disorders in the CNS, such as progressive supranuclear palsy and traumatic injury,27,37, –39 the role of tau in retinopathy is largely unknown. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.