Similarly, Tribbles homolog 2 functions as an oncogene in inducing murine acute myelogenous leukemia (AML) and cooperates with HoxA9 to accelerate the onset of AML in vivo, which is consistent with the fact that Trib2 is highly expressed in a particular subset of human AML patients [37]. This evidence concerns the gene TRIB2 and acute myeloid leukemia.