Similarly, Tribbles homolog 2 functions as an oncogene in inducing murine acute myelogenous leukemia (AML) and cooperates with HoxA9 to accelerate the onset of AML in vivo, which is consistent with the fact that Trib2 is highly expressed in a particular subset of human AML patients [37]. The gene discussed is HOXA9; the disease is acute myeloid leukemia.