CASP3 and diffuse large B-cell lymphoma: Importantly, comparison of the number of positive cells/mm2 present in tissue specimens of NGCB- and GCB-DLBLC, respectively, revealed a clear association with the GCB-DLBCL subtype: 3.3-fold more cleaved caspase 3 could be detected in these samples (p = 0.0041, Fig. 2b), whereas non-neoplastic GC-B did not exhibit any cleaved caspase 3 (p < 0.001, Fig. 2b).