Remarkably, five of the eight ERK target genes investigated showed increased expression in cytoplasmic high NR4A1 DLBCL: Expression of cFos, JUNB, cJUN, MXD1, and DUPS1 was 5.1 fold, 1.9 fold, 2.6 fold (p < 0.041), 7.6 fold, and 21.1 fold higher (p < 0.071, Fig. 3b), respectively. This evidence concerns the gene FOS and diffuse large B-cell lymphoma.