However, while we only detected nuclear and no cytoplasmic NR4A1 in the non-neoplastic GC-B, the percentage of aggressive lymphoma cells with NR4A1 in the cytoplasm varied between 5–80% (on average 27.1% for NGCB- and 48.5% for GCB-DLBCL, p = 0.0004, Fig. 1a–d). This evidence concerns the gene NR4A1 and diffuse large B-cell lymphoma.