Consistent with the downregulation of these pathways, the network model further showed that the transport of glucose and aspartate (SLC25A12), pyruvate (MCP1/2), malate and α-ketoglutarate (SLC25A11), and fatty acids (ACSL1 and CPT1B/2) were also downregulated in T2DM. The gene discussed is ACSL1; the disease is type 2 diabetes mellitus.