To the end, we developed a rapamycin-resistant Tsc2-null cell line (ELT3-V3R) based on Tsc2-null ELT3 cells (Eker rat uterine leiomyoma, or ELT3-V3) (Supplementary Fig. 5a–c). Here, TSC2 is linked to Uterine leiomyoma.