On multivariable analysis (adjusting for age, sex, presence of fibrosis, LVEF, NYHA, NT-proBNP, and CRP) severe AS remained significant, increasing serum OPG by 1.30 pmol/L (95% CI 0.002–2.60 pmol/L, p = 0.049). Here, TNFRSF11B is linked to aortic stenosis.