TNFRSF11B and aortic stenosis: However, for patients with chronic infarction pattern fibrosis on CMR, there was an effect on serum OPG on univariable analysis (p = 0.009), but there was only a trend on multivariable analysis when accounting for age, sex, AS severity, LVEF, NYHA, NT-proBNP, and CRP (p = 0.061).