TNFRSF11B and diabetes mellitus: On multivariable analysis (adjusted for age, sex, AVR/TAVR intervention, presence of myocardial fibrosis, NYHA class, CAD, diabetes, and hypertension), this effect remained statistically significant, with every 1 pmol/L increase in baseline serum OPG increasing the risk of death by 19% (HR 1.19, 95% CI 1.06–1.34; p = 0.004).