Co-expression with Usp12 did not reduce the risk of neuron death in the TDP-43 or the α-synuclein disease models (Fig. 2, Supplementary Table 4) as it did in our mHTT models (Fig. 1), indicating that Usp12 is not suppressing neurotoxicity generically. The gene discussed is TARDBP; the disease is glycogen storage disease VI.