EP300 and cancer: In cancer cells, USP24 increased p300 and β-TrCP, thus increasing the acetylation of histone H3 and the degradation of DNMT1 and IκB, resulting in the recruitment of histone H3 acetylation to the promoter region of IL-6, the reduction of DNA methylation, and the promotion of NF-κB nuclear translocation, thereby facilitating IL-6 expression (Fig. 9).