Hepatic metastasis and angiogenesis were also more severe when CL1–5 cells were mixed with M2 macrophages than they were when the cells were mixed with M2 macrophages after USP24 knockdown, suggesting that USP24 expression is essential in M2 macrophages for M2 macrophage-mediated lung cancer malignancy in vivo. This evidence concerns the gene USP24 and lung carcinoma.