UHRF1 and lung carcinoma: To investigate how USP24 regulates DNMT1 stability, the levels of ubiquitin like with PHD and ring finger domains 1 (UHRF1) and β-TrCP, two DNMT1-targeting E3 ligases, were examined in USP24-knockdown lung cancer cells (Fig. 6a and Supplementary Fig. 5a).