In this study, we discovered the underlying mechanisms by which USP24 not only promotes IκB degradation by stabilizing beta-transduction repeat containing E3 ubiquitin protein ligase (β-TrCP) in lung cancer cells but also induces the upregulation of NF-κB in M2 macrophages, resulting in an increase in IL-6 expression. The gene discussed is USP24; the disease is lung cancer.