Interestingly, reduction in the expression level of CASPR1/CNTN1 in pre‐clinical optic neuritis/EAE is associated with a concomitant decrease in RIBEYE expression indicating a close functional connection of these proteins in retinal ribbon synapses (Figs 2B2, D2, 3B2, C and 4B2, and EV5). Here, CNTNAP1 is linked to optic neuritis.