Since we found a portion of CASPR1 and CNTN1 to be associated with retinal ribbon synapses in close vicinity to the synaptic ribbons particularly in photoreceptor ribbon synapses, we asked whether this synaptic CASPR1/CNTN1 complex might be a neuroinflammatory target in mouse models of optic neuritis/MS. Here, CNTN1 is linked to optic neuritis.