PIK3C3 and chronic myelogenous leukemia, BCR-ABL1 positive: MiR-21 was up-regulated in chronic myeloid leukemia (CML), and treatment with antimiR-21 increased autophagy-related proteins Beclin-1, Vps34, and light chain 3 (LC3) II (LC3-II), eventually leading to an increase in autophagy flux [17].