CALR and breast neoplasm: For example, exposure to calreticulin derived from T. cruzi, in addition to promoting an antitumor immune response as mentioned above, may induce an antiangiogenic effect in breast tumors, both in vitro and in vivo, where T. cruzi calreticulin was able to inhibit the migration and proliferation of endothelial cells, possibly due to the internalization of this protein in the epithelial cells [33].