Therefore, on the basis of conflicting results regarding the association of adiponectin polymorphism with obesity and metabolic syndrome in different populations [12,26,2,29,31,42–45], the present investigation selected the two variants of ADIPOQ gene; -3971 A>G (rs822396) and +276 G>T (rs1501299) respectively, to investigate their putative association with obesity and metabolic syndrome in North Indian Punjabi population. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.