ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Our findings are consistent with a study conducted by Ramya et al. [16] revealing the novel association of the -3971A>G (rs822396) polymorphism with the generalized obesity in the south Indians These effects could be related to the fact that as an intronic variant, -3971A>G (rs822396) might affect the splicing of mRNA’s and leads to the formation of unstable or unprocessed mRNA’s which further impairs the adiponectin gene function.