In WT-infected cells, significant downregulation of the following markers occurred during tumor development (Fig 4A): CD45+ (92.5% to 80.1% in culture vs in tumors, respectively; p<0.0001), CD45+GFP+ (74.31% to 21.98%; p<0.0001), CD20+ (91.81% to 64.4%; p = 0.0009), CD22+ (44.61% to 8.05%; p<0.0001), and CD138+ (17.33% to 6.86%; p = 0.0001). This evidence concerns the gene CD22 and neoplasm.