It is highly upregulated in the inflamed synovial membrane of patients with osteoarthritis (OA) and rheumatoid arthritis (RA) [5] and an accelerated development of murine osteoarthritis in ADAM15 knockout mice suggested a homeostatic rather than a destructive role of ADAM15 in cartilage remodeling [6]. This evidence concerns the gene ADAM15 and osteoarthritis.