Furthermore, a significantly upregulated ADAM15 expression is detected in various solid tumors, e.g. breast and prostate, pancreas, lung and colon carcinomas [9–11] and its correlation with cancer progression and metastasis is associated with strong overexpression of ADAM15 as well as an increased migratory capacity of the tumor cells [12, 13]. The gene discussed is ADAM15; the disease is colon carcinoma.