It should be told that in this situation, that is in the earliest stage of human AIDs, there is usually a production of abzymes against only one specific antigen, for example SLE (anti‐DNA), MS (anti‐MBP) or autoimmune Hashimoto thyroiditis (anti‐thyroglobulin).8, 9, 10, 11, 12, 13 In the later stages of autoimmune pathologies, there is usually a very strong expansion of the abzymes repertoire. The gene discussed is MBP; the disease is systemic lupus erythematosus.