In favour of this assumption is the fact that the RAs of IgGs for hydrolysis of MBP, DNA and oligosaccharides from the CSF of MS patients are on average 50‐ to 60‐fold higher than Abs from the sera of the same patients.20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32 It seems reasonable to believe that additional amiss differentiation of lymphocytes occurs not only in different organs but already at the level of the bone marrow where the formation of cells producing auto‐Abs and abzymes results in an increase in enzymatic activities of abzymes in comparison with blood sera. This evidence concerns the gene MBP and myeloid sarcoma.