DDX41 and myeloid sarcoma: Numerous studies support the role of autoimmune mechanisms in the destruction of myelin, while the precise cause of MS remains unknown.1 Data indicate that activated myelin‐reactive CD4+ T cells may be principal mediators of MS.1 Several recent findings also specify an important role of B cells and autoantibodies (auto‐Abs) against myelin autoantigens in MS pathogenesis.1, 2, 3