EGFR and colorectal carcinoma: Previously, by reverse docking, Park et al demonstrated that ginsenoside Rb2 strongly interacts with both wild‐type and mutant forms of EGFR at different residues, such as MET769, GYS773, and GLU734 or PRO794, ASP855, and LYS716.18 Moreover, increasing evidences suggest that the expression and phosphorylation of EGFR directly correlate with the poor prognosis and metastasis in CRC.19, 20, 21, 22, 23, 24 Thus, we tested whether the down‐regulation of CSC and EMT signature by ginsenoside Rb2 occurs through EGFR signaling.