It was shown that ECM degradation via the increased activity of proteolytic enzymes, including MMPs, can lead to cancer cell migration and metastasis.16 To investigate whether ginsenoside Rb2 inhibited the migration and invasion of colorectal cancer cells through inhibition of the activity of MMP2, also known as a potential prognostic biomarker of colorectal cancer,17 we conducted a gelatin zymography assay with the culture supernatant, after treating HT29 cells with ginsenoside Rb2 at different concentrations for 4 days. The gene discussed is MMP2; the disease is colorectal cancer.