CXCR2 and endothelial dysfunction: In a uveal melanoma cell line, MALAT1 promoted cell migration through modulating miR-140 expression.30 In another study, MALAT1 upregulated the expression of miR-22-3p and its target genes CXCR2 and Akt.31 This resulted in protecting cells from ox-LDL-induced endothelial dysfunction by acting as a sponge.