FLNA and paroxysmal nocturnal hemoglobinuria: Bilateral and symmetrical cases, in particular, are characterised by a familial occurrence and a positive family history of epilepsy, even though it is associated with a clear female predominance.3 Bilateral and symmetrical PNH is an X-linked-dominant disease with linkage mapping to chromosome Xq28. 3,6,8,11,12 Mutations of the filamin A (FLNA) or filamin I (FLNI) gene have been identified.3,8,11,12