AVP and Borderline personality disorder: Studies demonstrated that AVP amounts in cerebrospinal fluid changed in direct proportion with the aggressive behaviour, but changed inversely with the plasma serotonin levels.15 It was reported adverse early life events increased AVP gene expression and AVP release, correlating with an increase in suicide attempts and aggressive behaviour.16,17 Thus, it could be considered that copeptin, the precursor of AVP, was related to self-mutilation in individuals with borderline personality disorder.