BRCA1 and breast cancer: The result revealed 168 UVs and polymorphisms in BRCA1/2 genes, 68 in BRCA1 and 100 in BRCA2. Cherbal and colleagues also performed BRCA1/2 mutation screening by HRM curve analysis and direct sequencing in 86 individuals from 70 Algerian BC families with history of BC, five mutations were detected in BRCA1 (c.83_84delTG, c.181T>G, c.798_799delTT, delEx2, delEx8) and 57 UVs/SNPs were revealed in both BRCA1 and BRCA2 [11].