BRCA1 and breast cancer: Mahfoudh et al. [14] performed a screening for germline mutations of BRCA1 in 16 Tunisian high-risk BC families, where six families were found with BRCA1 mutations: three truncating mutations were described in BRCA1 (c.798_799delTT, c.3331_3334delCAAG, c.5266dupC), one specific to Tunisian population (c.212 + 2insG) and the c.798_799delTT was suggested to be a Tunisian founder mutation based on its frequency (18%).