Many studies have been conducted to explore the association between the HER2 Ile655Val polymorphism and BC risk, a significant association among Africans was found for Val/Val v. Ile/Ile genotypes: odds ratio = 78, 95% confidence interval = 1.94–39.72, p = 0.35 for heterogeneity; for the recessive model Val/Val v. Ile/Val + Ile/Ile: odds ratio = 8.60, 95% confidence interval = 1.92–38.48, p = 0.31 for heterogeneity [21]. The gene discussed is ERBB2; the disease is breast cancer.