In these studies, mTOR expression has been identified in both OE33P and OE33R cells previously (data not shown) but the actual pathway through which LIF signals in OAC requires further investigation, especially since inhibition of mTOR has previously been shown to enhance radiosensitivity in oesophageal SCC, lung and pancreatic cancer [24, 35, 36]. The gene discussed is MTOR; the disease is familial pancreatic carcinoma.