EPHB6 and Hypertension: Another possible explanations are that (1) significantly associated SNPs might lie in the remaining 13.6 kb of the EPHB6 gene or even in the 3′ flanking sequence of EPHB6 gene, which are yet to be tested; or (2) while the lack of EPHB6 function leads to hypertension as demonstrated by the gene knockout results in the mouse model, it may simply be that there are no functional polymorphisms present within the analysed EPHB6 gene region in this human population that could result in loss of function of the gene.