While no SNPs in analyzed EPHB6 or EFNB1 regions were significantly associated with hypertension, three markers (one at a 3-gene experiment-wide significance level, and two at an EFNB3 single-gene significance level) located 5′ upstream of the EFNB3 gene start site were significantly associated with hypertension in this population even after correction for all of the covariates, which were also all significantly or near-significantly associated with hypertension. This evidence concerns the gene EFNB3 and hypertensive disorder.