EPHB6 and hypogonadism: This raises an interesting hypothesis relevant to human hypertension: for a subpopulation of males with loss-of-function mutations in the EPHB6 gene or genes in the EPHB6 signaling pathways, they might enjoy protection against hypertension; however, if they suffer from hypogonadism at the same time, they might become hypertensive due to detrimental effects of other genetic or environmental factors.