To further confirm the effect of the above ectopic expression miRNAs on baicalin-induced apoptosis in colon cancer cells, some apoptosis related target genes of these miRNAs were checked, such as HIC1 (miR-23a46), PDCD4 (miR-23a and miR-20547), PTEN (miR-10a48), E2F2 (miR-3149), E-cadherin (miR-151a50) and BCL-2 (miR-20451). This evidence concerns the gene HIC1 and malignant colon neoplasm.