CTGF (adj.p = 0.047), GSDMB (adj.p = 0.044) and CHRNA7 (adj.p = 0.043) were up-regulated between current smokers with no COPD vs. current smokers with COPD in bronchial brushing samples32 (Table 1). The gene discussed is CHRNA7; the disease is chronic obstructive pulmonary disease.