MT1-MMP is continuously internalised from the plasma membrane and trafficked to late endosomes, and the rate at which it returns to the plasma membrane is controlled by Rab GTPases (most particularly Rab27), VAMP7, and CLIC3—all of which are key to MT1-MMP mediated invasiveness of cancer cells through dense 3D microenvironments10–12. Here, MMP14 is linked to cancer.