The increased expression of three genes involved in self-renewal and in cell reprogramming, ΔNp7332NANOG and SOX232,48, in AML patients and the induction of ΔNp73 and NANOG upon BMP4 treatment supports the hypothesis that BMP4 could promote the reprogramming of cells towards immature leukemic cells. The gene discussed is BMP4; the disease is acute myeloid leukemia.