Interestingly, unlike the chronic phase of CML, in which we identified BMP2 and BMPR1B as driving the deregulation of the BMP pathway and SC/progenitor maintenance and expansion12, in AML BM cells, BMP4 and BMPR1A alterations were already detected at diagnosis. Here, BMPR1B is linked to chronic myelogenous leukemia, BCR-ABL1 positive.