Deleterious variants in low risk HBOC genes were found in two cancer patients in the genes FANCI (0.6%, 2/300), ERCC3 (0.6%), and in one patient in the genes ATR, FANCB, FANCC, FANCF, FANCL, FANCM, MLH1, RAD51C, POLH, RECQL4, SDHB and WRN (0.3%, 1/300) (Figure 1 and Figure 2). This evidence concerns the gene WRN and cancer.