In conclusion, elderly patients (≥70 years old) with a higher pre-discharge value of galectin-3 (≥17.6 ng/mL) together with BNP (≥500 pg/mL) might be included into a rigid clinical follow-up, performed by a general practitioner or HF out-patient clinic, providing a strict control of body weight, hydration status, pharmacological adherence, and clinical status in order to prevent multiple readmissions and mortality. Here, LGALS3 is linked to hydrops fetalis.