NPPB and hydrops fetalis: Indeed, while in OPTIMIZE-HF [22] patients over 65 years old, the BNP plasma value adequately predicted 1-year mortality and hospital readmission, the meta-analysis of Troughton et al., [30] clearly demonstrated how the survival benefit of a BNP-guided therapy post-discharge seemed to be effective only in younger (<75 years old) HF patients.