Although serum uPAR measured within the first 24 h from the onset of AP symptoms significantly predicted the complicated course of AP, including the need for ICU transfer and death, its diagnostic accuracy did not appear better than that of other inflammatory markers (IL-6, procalcitonin, CRP) nor the markers associated with endothelial dysfunction and hypercoagulability (sFlt-1, D-dimer). This evidence concerns the gene IL6 and thrombophilia.