The laboratory tests that have been proposed for the assessment of AP severity include proinflammatory [tumor necrosis factor-α (TNF-α), interleukins (IL): IL-6, IL-1β, IL-18, IL-8] and anti-inflammatory (IL-4, IL-10, IL-1 receptor antagonist) mediators, soluble receptors (soluble TNF-α receptor II), microRNAs, adhesive molecules (soluble intercellular adhesion molecule 1), growth factors (hepatocyte growth factor, tumor growth factor-β1), procalcitonin, and acute phase proteins [C-reactive protein (CRP), serum amyloid A] [5,9,10,11]. Here, TNF is linked to alkaline phosphatase measurement.