GPT and hepatitis A virus infection: In one study of 1068 Taiwanese HBeAg negative patients that had been diagnosed as HBV carriers, infected with HBV genotype B or C, the relationship between HBsAg level > 1000 IU/mL and the development of HBeAg-negative hepatitis in 13 years follow up was found to be significant (hazard ratio (HR) = 1.5, 95% CI = 1.2–1.9) and HBsAg < 1000 IU/mL in combination with low HBV DNA and ALT were found to be useful for identifying minimal-risk HBV carriers [80].