Concomitant with the up-regulation of KCa3.1 and NDPK-B, TRAM-34 (1 μM)-induced depolarization responses in CD4+ T cells were significantly stronger in IBD model mice than in the normal group (n = 17 and 10, p < 0.01) (Figure 1D,E). The gene discussed is KCNN4; the disease is inflammatory bowel disease.