KCNN4 and inflammatory bowel disease: Similarly, in the splenic CD4+CD25− T cells of IBD model mice, the expression levels of HDAC2 and HDAC3 isoforms were specifically up-regulated (Figure 3B,C), and the pharmacological inhibition of HDAC2 or HDAC3 resulted in the significant down-regulation of KCa3.1 (Figure 5).