Among the eleven isoforms that were examined, relatively high expression levels of HDAC1, HDAC2, HDAC3, and HDAC7 were found in CD4+CD25− T cells, and a significant increase in the expression levels of HDAC2 and HDAC3 was noted in IBD model mice (Figure 3A–D). This evidence concerns the gene HDAC3 and inflammatory bowel disease.