NR3C2 and heart failure: Indeed, MR activation in cardiac myocytes results in the upregulation of numerous ion channels including voltage-gated Na+ channels [7], voltage-gated K+ channels [8], voltage-gated Ca2+ channels [9,10,11], and hyperpolarization-activated cyclic nucleotide-gated channels HCN4 [12], which promotes hypertrophy development and heart failure [8,13,14].