However, FXS larvae with genetic reduction of CenG1A expression showed the inhibition of the startle response to the pulse induced by the precedent prepulse, suggesting the presence of PPI (Fig. 4A, CenG1A/+; fmr1: 0.1 s interval, 56.4%±4.5%, n=10, P=0.0018; 0.3 s interval, 53.4%±3.5%, n=30, P<0.0001; 1.0 s interval, 65.6%±4.8%, n=10, P=0.086, compared with the value of pulse only, ANOVA and post-hoc Scheffe's test). The gene discussed is FMR1; the disease is fragile X syndrome.