AATF and precursor B-cell acute lymphoblastic leukemia: In particular, in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), Che-1 is required for control of the expression of several genes involved in cell growth, as demonstrated by ChiP-seq assay showing the presence of Che-1 on 2,205-derived TSSs, including promoters of cell cycle regulatory genes.