Using this method, 48 patients met criteria for CKD, and we found significantly elevated risks of NAE in multivariate models: HR 3.29 (95% CI 1.66–6.50; p = 0.001) for current CD4/CD8 ratio < 0.3) and HR 2.46 (95% CI 1.44–4.20; p = 0.001) for those with ratios between 0.3 and 0.45, vs. > 0.45 as the reference group. This evidence concerns the gene CD4 and chronic kidney disease.